Recent Global Patterns in Prostate Cancer Incidence and Mortality Rates

MaryBeth B Culp 1, Isabelle Soerjomataram 2, Jason A Efstathiou 3, Freddie Bray 2, Ahmedin Jemal 4

Affiliations Expand

PMID: 31493960

DOI: 10.1016/j.eururo.2019.08.005

Abstract

Context: Previous studies have reported significant variation in prostate cancer rates and trends mainly due to differences in detection practices, availability of treatment, and underlying genetic susceptibility.

Objective: To assess recent worldwide prostate cancer incidence, mortality rates, and trends using up-to-date incidence and mortality data.

Evidence acquisition: We present estimated age-standardized prostate cancer incidence and mortality rates by country and world regions for 2018 based on the GLOBOCAN database. We also examined rates and temporal trends for incidence (44 countries) and mortality (76 countries) based on data series from population-based registries.

Evidence synthesis: The highest estimated incidence rates were found in Australia/New Zealand, Northern America, Western and Northern Europe, and the Caribbean, and the lowest rates were found in South-Central Asia, Northern Africa, and South-Eastern and Eastern Asia. The highest estimated mortality rates were found in the Caribbean (Barbados, Trinidad and Tobago, and Cuba), sub-Saharan Africa (South Africa), parts of former Soviet Union (Lithuania, Estonia, and Latvia), whereas the lowest rates were found in Asia (Thailand and Turkmenistan). Prostate cancer incidence rates during the most recent 5 yr declined (five countries) or stabilized (35 countries), after increasing for many years; in contrast, rates continued to increase for four countries in Eastern Europe and Asia. During the most recent 5 data years, mortality rates among the 76 countries examined increased (three countries), remained stable (59 countries), or decreased (14 countries).

Conclusions: As evident from available data, prostate cancer incidence and mortality rates have been on the decline or have stabilized recently in many countries, with decreases more pronounced in high-income countries. These trends may reflect a decline in prostate-specific antigen testing (incidence) and improvements in treatment (mortality).

Patient summary: We examined recent trends in prostate cancer incidence and mortality rates in 44 and 76 countries, respectively, and found that rates in most countries stabilized or decreased.

Keywords: Global patterns; Prostate cancer; Prostate-specific antigen testing.

Copyright © 2019 European Association of Urology. Published by Elsevier B.V. All rights reserved.

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Comment in

• What Goes Up Must Come Down: Identifying Truth from Global Prostate Cancer Epidemiology.
  Nyame YA, Gore JL.Eur Urol. 2020 Jan;77(1):53-54. doi: 10.1016/j.eururo.2019.09.018. Epub 2019 Oct 16.PMID: 31627967 No abstract available.
• Re: MaryBeth B. Culp, Isabelle Soerjomataram, Jason A. Efstathiou, Freddie Bray, Ahmedin Jemal. Recent Global Patterns in Prostate Cancer Incidence and Mortality Rates. Eur Urol 2020;77:38-52.
  Patasius A, Smailyte G.Eur Urol. 2020 May;77(5):e132. doi: 10.1016/j.eururo.2019.11.030. Epub 2019 Dec 13.PMID: 31843337 No abstract available.

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